Medicinal composition containing trifluridine and tipiracil hydrochloride and preparation method thereof

The invention provides a pharmaceutical composition containing trifluridine and tipiracil hydrochloride. The pharmaceutical composition can be prepared into trifluridine and tipiracil hydrochloride tablets. The pharmaceutical composition comprises trifluridine, tipiracil hydrochloride, a filler, a disintegrating agent and a lubricant, wherein the molar ratio of trifluridine to tipiracil hydrochloride is 1: 0.5. The invention also provides a preparation method of the pharmaceutical composition. The pharmaceutical composition has the characteristics of simple preparation method, rapid dissolution, good stability and the like. 本发明提供了一种含有曲氟尿苷盐酸替匹嘧啶的药物组合物，所述药物组合物可以制成曲氟尿苷替匹嘧啶片。本发明所述药物组合物包括曲氟尿苷、盐酸替匹嘧啶、填充剂、崩解剂和润滑剂，曲氟尿苷与盐酸替匹嘧啶的摩尔比为1:0.5。本发明还提供了该药物组合物的制备方法。所述药物组合物具有制备方法简便，溶出迅速，稳定性良好等特点。