2apos; -(7, 7-dimethyl-1apos;-(7, 7-dimethyl-1apos; h, 7H-spiro [furo [3, 4-b] pyridine-5, 4apos; -piperidine]-1apos; -yl)-1, 3-dihydro-4apos,-(-)-1, 3-dihydro-4apos; h-spiro [indene-2, 5apos; -[1, 3] oxazole]-4apos; synthesis of-ketones and crystalline forms thereof

2apos; -(7, 7-dimethyl-1apos;-(7, 7-dimethyl-1apos; h, 7H-spiro [furo [3, 4-b] pyridine-5, 4apos; -piperidine]-1apos; -yl)-1, 3-dihydro-4apos,-(-)-1, 3-dihydro-4apos; h-spiro [indene-2, 5apos; -[1, 3] oxazole]-4apos; synthesis of-ketones and crystalline forms thereof

The present invention provides a process for the manufacture of substituted 2 '-(7, 7-dimethyl-1' H, 7H-spiro [furo [3, 4-b] pyridine-5, 4 '-piperidine]-1'-yl)-1, 3-dihydro-4 'H-spiro [indene-2, 5'-[1, 3] oxazole]-4 '-ones. Also disclosed are compounds useful as in...

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Hauptverfasser: BACHMANN STEFAN, BIEGLER RAPHAEL, FANTASIA SERENA MARIA, ADAM, JEAN-MICHEL, GROSS-SANDER KATJA, JUGEN TU, DAUTE PASCAL, JAMES PHILIP, TONAZZI SANDRO, SPERL PAUL, TOSATTI PAOLO
Format: Patent
Sprache:chi ; eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:The present invention provides a process for the manufacture of substituted 2 '-(7, 7-dimethyl-1' H, 7H-spiro [furo [3, 4-b] pyridine-5, 4 '-piperidine]-1'-yl)-1, 3-dihydro-4 'H-spiro [indene-2, 5'-[1, 3] oxazole]-4 '-ones. Also disclosed are compounds useful as intermediates in the processes according to the invention. # imgabs0 # 本发明提供制造经取代的2'-(7,7-二甲基-1'H,7H-螺[呋喃并[3,4-b]吡啶-5,4'-哌啶]-1'-基)-1,3-二氢-4'H-螺[茚-2,5'-[1,3]噁唑]-4'-酮的方法。还公开了在根据本发明所述的方法中用作中间体的化合物。#imgabs0#