Antibody-drug conjugates

The present invention relates to conjugates containing a) an antibody or antibody fragment, and b) a specific protease of the immunoglobulin G (IgG) hinge region. The invention also relates to compositions comprising at least one such conjugate, and to the use of the conjugate as a medicament, in particular for the treatment of diseases caused by autoantibodies. 本发明涉及缀合物，其含有a)抗体或抗体片段，和b)免疫球蛋白G(IgG)铰链区的特异性蛋白酶。本发明还涉及包含至少一种这种缀合物的组合物，以及该缀合物作为药物的用途，特别是用于治疗由自身抗体引起的疾病。