Polynucleotides encoding CD19/CD3 bispecific antibodies

The present application relates to pharmaceutical compositions comprising a messenger ribonucleic acid (mRNA) encoding a CD19/CD3 bispecific antibody, and lipid nanoparticles comprising the messenger ribonucleic acid. In other aspects, the present application relates to methods of treating diseases,...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	YANG ZHENXING, YUAN JIJUN, ZHONG XIA, DU LIANG, QIN QIANSHAN, YING BO
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Online-Zugang:	Volltext bestellen
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Beschreibung
Zusammenfassung:	The present application relates to pharmaceutical compositions comprising a messenger ribonucleic acid (mRNA) encoding a CD19/CD3 bispecific antibody, and lipid nanoparticles comprising the messenger ribonucleic acid. In other aspects, the present application relates to methods of treating diseases, such as cancer, using the pharmaceutical compositions provided herein. 本申请涉及药物组合物，所述药物组合物包含编码CD19/CD3双特异性抗体的信使核糖核酸(mRNA)以及包含所述信使核糖核酸的脂质纳米颗粒。在其他方面中，本申请涉及使用本文所提供的药物组合物治疗诸如癌症的疾病的方法。