Quercetin-piperine co-amorphous substance with synergistic anti-oxidation and absorption-promoting effects and preparation method of quercetin-piperine co-amorphous substance

According to the quercetin-piperine co-amorphous substance with the synergistic anti-oxidation and absorption-promoting effects and the preparation method of the quercetin-piperine co-amorphous substance, the amorphous substance only composed of quercetin and piperine is provided, other auxiliary ma...

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Hauptverfasser: DONG ZHI, TAN QIURU, YANG ZHIZHONG, WANG WENPING, ZOU ZIBIN, KE JIN, TIAN SHUANG, WANG JIAO, SHU QIJIANG
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:According to the quercetin-piperine co-amorphous substance with the synergistic anti-oxidation and absorption-promoting effects and the preparation method of the quercetin-piperine co-amorphous substance, the amorphous substance only composed of quercetin and piperine is provided, other auxiliary materials do not need to be added, the preparation method is simple and convenient, both quercetin and piperine are derived from medicinal and edible plants and are common natural active substances, and the quercetin and piperine co-amorphous substance is free of toxic and side effects. The co-amorphous substance prepared by the invention can reduce the solubility of the two medicines, but unexpectedly, the co-amorphous substance can spontaneously form uniform particles, has excellent in-vivo and in-vitro oxidation resistance, can improve the oral bioavailability of the two components at the same time, and is beneficial to development of efficient compound preparations. 本发明一种具有协同抗氧化及促吸收效应的槲皮素-胡椒碱共无定形物及其制备方法,提供了一种仅由二者