Application of cedar leaf alcohol extract in preparation of medicine for inhibiting liver cancer

The invention provides an application of a cedar leaf alcohol extract in preparation of a medicine for inhibiting liver cancer, and belongs to the technical field of anti-cancer medicines. The cedar leaf alcohol extract provided by the invention can obviously reduce the volume growth rate and tumor...

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Hauptverfasser: LV JIHUA, NONG YUNKAI, DENG YUYIN, LI LI, LU GUOSHOU, LIU YING
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention provides an application of a cedar leaf alcohol extract in preparation of a medicine for inhibiting liver cancer, and belongs to the technical field of anti-cancer medicines. The cedar leaf alcohol extract provided by the invention can obviously reduce the volume growth rate and tumor weight of transplanted tumors and promote tumor cell apoptosis. Moreover, after treatment with the cedar leaf alcohol extract, the heterotypic property of tumor cells is reduced, large tumor tissues are necrotized, the expression quantity of Ki-67 protein in the tumor tissues is remarkably reduced, inflammatory cell infiltration is remarkable, and the levels of inflammatory factors IL-6 and IL-18 in blood are remarkably increased. 本发明提供了一种杉叶醇提取物在制备抑制肝癌药物中的应用,属于抗癌药物技术领域。本发明提供的杉叶醇提取物可明显降低移植瘤体积增长速率和瘤重,促使肿瘤细胞凋亡。并且,杉叶醇提物处理后肿瘤细胞异型性降低,瘤组织大片坏死,瘤组织中Ki-67蛋白的表达量显著降低,炎症细胞浸润显著,血液中炎症因子IL-6、IL-18水平显著升高。