Application of vinpocetine in preparation of medicine for promoting angiogenesis

The invention discloses application of vinpocetine in preparation of a medicine for promoting angiogenesis. Through a series of deep studies, the inventor finds that vinpocetine as a PDE1A inhibitor can promote tubule formation and migration of OGD/R model human brain microvascular endothelial cells in vitro through cooperation of a cGMP-PKG pathway and an HIF-1alpha-VEGF pathway; the cerebral infarction area of MCAO/R model rats is reduced in vivo, and the blood vessel density and the number of new blood vessels of ischemic penumbra are remarkably increased, so that ischemia-induced angiogenesis is promoted. Vinpocetine is used for treating cerebral arterial thrombosis to generate one-target double-effect and '1 + 1 > 2' superposed effect. 本发明公开了长春西汀在制备促进血管新生药物中的应用。本发明的发明人通过一系列的深入研究发现长春西汀作为PDE1A抑制剂可以通过cGMP-PKG途径协同HIF-1α-VEGF途径，在体外促进OGD/R模型人脑微血管内皮细胞的小管形成和迁移，在体内降低MCAO/R模型大鼠脑梗死面积并显著增加缺血半暗带的血管密度和新生血管数，进而促进缺血诱导的血管新生。长春西汀用于治疗缺血性脑卒中将产生一靶双效，"1+1＞2"的叠加作用效果。