Lentiviral vectors

The invention relates to the production of lentiviral vectors. More specifically, the present invention relates to nucleotide sequences encoding a lentiviral vector genome comprising any one or more of the following: a modified 3 'LTR, a modified 5' LTR, a vector intron, at least one cis-a...

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Bibliographische Detailangaben
Hauptverfasser:	WRIGHT JUSTIN, FARLEY DARRYL, NOGUEIRA CAMILO
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention relates to the production of lentiviral vectors. More specifically, the present invention relates to nucleotide sequences encoding a lentiviral vector genome comprising any one or more of the following: a modified 3 'LTR, a modified 5' LTR, a vector intron, at least one cis-acting sequence, and/or an interfering RNA. Methods and uses of such nucleotide sequences are also encompassed. 本发明涉及慢病毒载体的产生。更具体地，本发明涉及编码慢病毒载体基因组的核苷酸序列，所述慢病毒载体基因组包含以下任何一种或多种：修饰的3'LTR；修饰的5'LTR；载体内含子；至少一种顺式作用序列；和/或干扰RNA。本发明还涵盖此类核苷酸序列的方法和用途。