Pyrimidine heterocyclic compound containing N-methylpiperazine structure as well as preparation method and application of pyrimidine heterocyclic compound

The invention discloses a pyrimidine heterocyclic compound containing an N-methylpiperazine structure as well as a preparation method and application thereof, belongs to the technical field of medicines, and particularly discloses the pyrimidine heterocyclic compound containing the N-methylpiperazine structure as shown in a general formula I or pharmaceutically acceptable salt thereof, the compound has a function of remarkably inhibiting at least one EGFR kinase mutant, particularly has a powerful inhibiting effect on EGFRL858R/T790M/C797S mutation closely related to generation of drug resistance, and meanwhile has good selectivity on EGFRWT, and compared with a first-generation inhibitor and a second-generation inhibitor in current research and development, the compound has the advantage that the compound has a remarkable effect on inhibiting the EGFRL858R/T790M/C797S mutation. The compound disclosed by the invention has a novel chemical structure, has very high inhibitory activity and selectivity on EGFR (e