Preparation method of glabridin

The invention discloses a preparation method of glabridin, and belongs to the technical field of medicine synthesis. According to the method disclosed by the invention, resorcinol containing a protecting group is taken as a starting raw material, and finally, the glabridin is efficiently synthesized through five steps of reaction, namely acylation, nucleophilic addition with a metal reagent, methyl protection removal and ring closing, affinity substitution, high-temperature rearrangement and carbonyl reduction. The used reagent is safe and low in toxicity, less waste liquid and waste residue are generated, the post-treatment operation is simple, amplification is facilitated, the step is short, less time is consumed, the cost is low, the total yield is high, the purity of the final product reaches 99.7%, and the method is suitable for industrial production. 本发明公开了一种光甘草定的制备方法，属于药物合成技术领域。本发明方法以含有保护基的间苯二酚为起始原料，经过酰基化、与金属试剂的亲核加成、脱出甲基保护合环、亲和取代、高温重排并还原羰基共五步反应，最终高效合成光甘草定，与现有合成方法相比，本发明所用原料易得，所用试剂安全低毒、产生的废液废渣少、后处理操作简单、利