Application of recombinant TGFBI protein in latticed corneal dystrophy

The invention discloses an application of a recombinant TGFBI protein in latticed corneal dystrophy, and belongs to the technical field of biological medicines. The invention provides an application of a recombinant TGFBI protein and a reagent for expressing the recombinant TGFBI protein in preparation of a medicament for treating latticed corneal dystrophy, and proves that the TGFBI recombinant protein can promote corneal epithelium injury repair of a latticed corneal dystrophy mouse model when applied to eyes; corneal stroma injection of the TGFBI recombinant protein can promote repair of corneal epithelium injury of a mouse model with latticed corneal dystrophy, corneal limbal stroma injection of an AAV carrier carrying a Tgfbi gene can promote repair of epithelium injury of a mouse with TGFBI point mutation, and therefore related reagents of the recombinant TGFBI protein have the potential of treating LCD. 本发明公开了重组TGFBI蛋白在格子状角膜营养不良中的应用，属于生物医药技术领域。本发明提供了重组TGFBI蛋白以及表达重组TGFBI蛋白的试剂在制备治疗格子状角膜营养不良的药剂中的应用，证实TGFB