Nanocrystalline preparation of ROCK2 inhibitor and preparation method thereof

The invention discloses a nanocrystal preparation and a preparation method thereof. The nanocrystal preparation comprises a ROCK2 inhibitor and a stabilizer. The invention also relates to application of the nanocrystalline preparation in preventing, relieving and/or treating selected diseases and me...

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Bibliographische Detailangaben
Hauptverfasser: ZHANG ZHIBING, XU JIAJIA, LU DI, LU YONGJIE, NIU SHENGPAN, ZHANG SHASHA, ZHU CHAOLU
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses a nanocrystal preparation and a preparation method thereof. The nanocrystal preparation comprises a ROCK2 inhibitor and a stabilizer. The invention also relates to application of the nanocrystalline preparation in preventing, relieving and/or treating selected diseases and medical diseases, especially diseases such as idiopathic pulmonary fibrosis, fatty liver diseases and/or steatohepatitis, graft versus host diseases after hematopoietic stem cell transplantation or virus infection. 一种纳米晶制剂及其制备方法,所述纳米晶制剂包含ROCK2抑制剂和稳定剂。还涉及所述纳米晶制剂在用于预防、缓解和/或治疗所选疾病及医学病症,尤其是特发性肺纤维化、脂肪性肝病和/或脂肪性肝炎、造血干细胞移植后的移植物抗宿主病或者病毒感染等疾病中的用途。