Single-domain antibody targeting mesothelin, chimeric antigen receptor and application of single-domain antibody and chimeric antigen receptor
The invention relates to the technical field of immunotherapy, and provides a mesothelin-targeting single-domain antibody, a mesothelin-targeting chimeric antigen receptor (CAR) constructed by using the single-domain antibody, and an engineered immune effector cell containing the CAR. The invention...
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| creator | HE YUCHEN WENG MIMI YAN XIU XU QIPIN ZHOU DAN ZHOU XIA |
| description | The invention relates to the technical field of immunotherapy, and provides a mesothelin-targeting single-domain antibody, a mesothelin-targeting chimeric antigen receptor (CAR) constructed by using the single-domain antibody, and an engineered immune effector cell containing the CAR. The invention also provides application of the single-domain antibody targeting mesothelin, the chimeric antigen receptor and the engineered immune effector cell containing the CAR in preparation of drugs for diagnosis, prevention and/or treatment of mesothelin expression related diseases or symptoms.
本发明涉及免疫治疗技术领域，本发明提供了一种靶向间皮素的单域抗体、利用该单域抗体构建的靶向间皮素的嵌合抗原受体(CAR)以及包含该CAR的工程化的免疫效应细胞。本发明还提供了靶向间皮素的单域抗体、嵌合抗原受体以及包含该CAR的工程化的免疫效应细胞在制备用于诊断、预防和/或治疗与间皮素表达相关的疾病或病症的药物中的用途。 |
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本发明涉及免疫治疗技术领域，本发明提供了一种靶向间皮素的单域抗体、利用该单域抗体构建的靶向间皮素的嵌合抗原受体(CAR)以及包含该CAR的工程化的免疫效应细胞。本发明还提供了靶向间皮素的单域抗体、嵌合抗原受体以及包含该CAR的工程化的免疫效应细胞在制备用于诊断、预防和/或治疗与间皮素表达相关的疾病或病症的药物中的用途。</description><language>chi ; eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; MEASURING ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PHYSICS ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; TESTING ; VINEGAR ; WINE</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240618&DB=EPODOC&CC=CN&NR=118206661A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240618&DB=EPODOC&CC=CN&NR=118206661A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>HE YUCHEN</creatorcontrib><creatorcontrib>WENG MIMI</creatorcontrib><creatorcontrib>YAN XIU</creatorcontrib><creatorcontrib>XU QIPIN</creatorcontrib><creatorcontrib>ZHOU DAN</creatorcontrib><creatorcontrib>ZHOU XIA</creatorcontrib><title>Single-domain antibody targeting mesothelin, chimeric antigen receptor and application of single-domain antibody and chimeric antigen receptor</title><description>The invention relates to the technical field of immunotherapy, and provides a mesothelin-targeting single-domain antibody, a mesothelin-targeting chimeric antigen receptor (CAR) constructed by using the single-domain antibody, and an engineered immune effector cell containing the CAR. The invention also provides application of the single-domain antibody targeting mesothelin, the chimeric antigen receptor and the engineered immune effector cell containing the CAR in preparation of drugs for diagnosis, prevention and/or treatment of mesothelin expression related diseases or symptoms.
本发明涉及免疫治疗技术领域，本发明提供了一种靶向间皮素的单域抗体、利用该单域抗体构建的靶向间皮素的嵌合抗原受体(CAR)以及包含该CAR的工程化的免疫效应细胞。本发明还提供了靶向间皮素的单域抗体、嵌合抗原受体以及包含该CAR的工程化的免疫效应细胞在制备用于诊断、预防和/或治疗与间皮素表达相关的疾病或病症的药物中的用途。</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</subject><subject>MEASURING</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PHYSICS</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>TESTING</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjDEKwkAQRdNYiHqHsTdgFIKtBMXKRvswbibJwGZm2Z3GS3hmo1gqWH14__Gm2ePC0nnKGx2QBVCMb9rcwTB2ZOMHAyW1njzLClzPA0V2b68jgUiOgmkcQQMYgmeHxiqgLaTv5Zf5szPPJi36RIvPzrLl8XCtTjkFrSkFdCRkdXUuit1mXZZlsd_-4zwBWPBPSQ</recordid><startdate>20240618</startdate><enddate>20240618</enddate><creator>HE YUCHEN</creator><creator>WENG MIMI</creator><creator>YAN XIU</creator><creator>XU QIPIN</creator><creator>ZHOU DAN</creator><creator>ZHOU XIA</creator><scope>EVB</scope></search><sort><creationdate>20240618</creationdate><title>Single-domain antibody targeting mesothelin, chimeric antigen receptor and application of single-domain antibody and chimeric antigen receptor</title><author>HE YUCHEN ; WENG MIMI ; YAN XIU ; XU QIPIN ; ZHOU DAN ; ZHOU XIA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN118206661A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2024</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</topic><topic>MEASURING</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PHYSICS</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>TESTING</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>HE YUCHEN</creatorcontrib><creatorcontrib>WENG MIMI</creatorcontrib><creatorcontrib>YAN XIU</creatorcontrib><creatorcontrib>XU QIPIN</creatorcontrib><creatorcontrib>ZHOU DAN</creatorcontrib><creatorcontrib>ZHOU XIA</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>HE YUCHEN</au><au>WENG MIMI</au><au>YAN XIU</au><au>XU QIPIN</au><au>ZHOU DAN</au><au>ZHOU XIA</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Single-domain antibody targeting mesothelin, chimeric antigen receptor and application of single-domain antibody and chimeric antigen receptor</title><date>2024-06-18</date><risdate>2024</risdate><abstract>The invention relates to the technical field of immunotherapy, and provides a mesothelin-targeting single-domain antibody, a mesothelin-targeting chimeric antigen receptor (CAR) constructed by using the single-domain antibody, and an engineered immune effector cell containing the CAR. The invention also provides application of the single-domain antibody targeting mesothelin, the chimeric antigen receptor and the engineered immune effector cell containing the CAR in preparation of drugs for diagnosis, prevention and/or treatment of mesothelin expression related diseases or symptoms.
本发明涉及免疫治疗技术领域，本发明提供了一种靶向间皮素的单域抗体、利用该单域抗体构建的靶向间皮素的嵌合抗原受体(CAR)以及包含该CAR的工程化的免疫效应细胞。本发明还提供了靶向间皮素的单域抗体、嵌合抗原受体以及包含该CAR的工程化的免疫效应细胞在制备用于诊断、预防和/或治疗与间皮素表达相关的疾病或病症的药物中的用途。</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE |
| title | Single-domain antibody targeting mesothelin, chimeric antigen receptor and application of single-domain antibody and chimeric antigen receptor |
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