Single-domain antibody targeting mesothelin, chimeric antigen receptor and application of single-domain antibody and chimeric antigen receptor

The invention relates to the technical field of immunotherapy, and provides a mesothelin-targeting single-domain antibody, a mesothelin-targeting chimeric antigen receptor (CAR) constructed by using the single-domain antibody, and an engineered immune effector cell containing the CAR. The invention also provides application of the single-domain antibody targeting mesothelin, the chimeric antigen receptor and the engineered immune effector cell containing the CAR in preparation of drugs for diagnosis, prevention and/or treatment of mesothelin expression related diseases or symptoms. 本发明涉及免疫治疗技术领域，本发明提供了一种靶向间皮素的单域抗体、利用该单域抗体构建的靶向间皮素的嵌合抗原受体(CAR)以及包含该CAR的工程化的免疫效应细胞。本发明还提供了靶向间皮素的单域抗体、嵌合抗原受体以及包含该CAR的工程化的免疫效应细胞在制备用于诊断、预防和/或治疗与间皮素表达相关的疾病或病症的药物中的用途。