Enhanced chimeric antigen receptors and uses thereof

Provided herein are a CD5-specific antigen-specific single-chain variable fragment (scFv), chimeric antigen receptors (CARs) comprising the scFv, immune cells expressing the CARs, and methods of use thereof in the treatment of immune diseases. 本文提供了一种CD5特异性的抗原特异性单链可变片段(scFv)，包含所述scFv的嵌合抗原受体(CARs)，表达...

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Bibliographische Detailangaben
Hauptverfasser:	REZVANI KATY, ANG SONNY, SPAHR PAUL, LAU ERIC
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Provided herein are a CD5-specific antigen-specific single-chain variable fragment (scFv), chimeric antigen receptors (CARs) comprising the scFv, immune cells expressing the CARs, and methods of use thereof in the treatment of immune diseases. 本文提供了一种CD5特异性的抗原特异性单链可变片段(scFv)，包含所述scFv的嵌合抗原受体(CARs)，表达所述CAR的免疫细胞及其在免疫疾病治疗中的使用方法。