Azoline ammonium quinoline carboxamide analogue as well as pharmaceutical composition, preparation method and medical application thereof

The invention relates to the field of medicinal chemistry and pharmacotherapeutics, in particular to an ammonium oxazoline quinoline carboxamide analogue as well as a pharmaceutical composition, a preparation method and medical application of the ammonium oxazoline quinoline carboxamide analogue. The chemical structure of the compound is shown as a formula I: # imgabs0 #. According to the compound disclosed by the invention, tests on the binding activity of actin binding protein 2, the activity of human airway smooth muscle cells and the activity in an animal body show that the compound has the binding activity of actin binding protein 2, the activity of relaxing the human airway smooth muscle cells and the activity of reducing rat airway resistance; the composition can be used for treating asthma diseases. 本发明涉及药物化学和药物治疗学领域，具体涉及唑啉铵喹啉甲酰胺类似物及其药物组合物、制备方法和医药用途。所述化合物的化学结构如式I所示：#imgabs0#本发明的化合物通过对肌动蛋白结合蛋白2结合活性、人气道平滑肌细胞活性及动物体内活性测试发现该类化合物具有肌动蛋白结合蛋白2结合活性、舒张人气道平滑肌细胞活性和降低鼠气道阻力活性，可以用于治疗哮喘疾病。