Application of Liproxstatin-1 in preparation of medicine for preventing and treating organ failure caused by diquat poisoning

The invention relates to the field of medicines, in particular to application of Liproxstat in-1 in preparation of a medicine for preventing and treating organ failure caused by diquat poisoning. At present, no report that diquat induces ferroptosis of cells exists, and no report that Lip-1 protects diquat to induce mouse organ failure to cause death exists. In order to solve the technical problems, the invention provides the application of the Liproxstat in-1 in preparation of the medicine for preventing and treating organ failure caused by diquat poisoning. A series of tests prove that the Lip-1 obviously reduces the fatality rate of mice caused by diquat, obviously reduces the organ injury of the mice caused by diquat, and obviously improves the biochemical indexes of the mice. 本发明涉及医药领域，尤其涉及一种Liproxstat in-1在制备防治敌草快中毒致器官衰竭的药物中的应用。目前未有敌草快诱导细胞发生铁死亡的报道，亦没有Lip-1保护敌草快诱导小鼠器官衰竭引发死亡的报道。本发明要解决的技术问题，在于提供一种Liproxstat in-1在制备防治敌草快中毒致器官衰竭的药物中的应用。本发明通过一系列试验验证，Lip-1显著降低敌草快引起的小鼠致死率，显著降低敌草快引起的小鼠脏器损伤，显著改善小鼠生化指标。