COMPOSITION FOR PREVENTING OR TREATING PERIPHERAL T-CELL LYMPHOMA, CONTAINING DUAL INHIBITORS OF PI3K AND DNA-PK

The present invention relates to a composition for preventing or treating peripheral T-cell lymphoma, comprising a compound represented by chemical formula 1 or a pharmaceutically acceptable salt thereof. Specifically, the present invention relates to a pharmaceutical composition capable of effectiv...

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Hauptverfasser: KIM, BONG SEOK, JEON YUN-KYUNG, KIM JONG YEON, PARK KYUNG-YOON, JEON BYEONG WOOK, KIM YUN-SIK, MATHUR ANUSH H, KIM TAE-MIN, YOUN DEOKHYUN, JUNG SEUNG-HEE, CHAVES, JOHN, M, KIM SUK-JIN, ZHENG XIAOSHUN, WANG SHENGHAO, LEE JOO-HAN
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The present invention relates to a composition for preventing or treating peripheral T-cell lymphoma, comprising a compound represented by chemical formula 1 or a pharmaceutically acceptable salt thereof. Specifically, the present invention relates to a pharmaceutical composition capable of effectively improving peripheral T cell lymphoma by reducing regulatory T cells and increasing CD8 + T cells. The pharmaceutical composition of the present invention can exhibit anti-cancer activity on peripheral T cell lymphoma by reducing regulatory T cells that inhibit immune response and increasing CD8 + T cells that exhibit anti-cancer effects. Moreover, the pharmaceutical composition of the present invention has excellent safety and tolerance, and thus can be used for the treatment of peripheral T-cell lymphoma. 本发明涉及一种包含化学式1所表示的化合物或其药学上可接受的盐的外周T细胞淋巴瘤的预防或治疗用组合物。具体而言,本发明涉及一种能够通过减少调节T细胞并增加CD8+T细胞来能够有效地改善外周T细胞淋巴瘤的药物组合物。本发明的药物组合物通过减少抑制免疫反应的调节T细胞并增加表现出抗癌效果的CD8+T细胞,能够对外周T细胞淋巴瘤表现出抗癌活性。并且,本发明的药物组合物,其安全性及耐受性优异,因此能够用于外周T细胞淋巴瘤的