Biomarker combination, diagnostic kit containing biomarker combination and application of biomarker combination

The invention discloses a biomarker combination, a diagnostic kit containing the biomarker combination and application of the biomarker combination. The biomarker combination comprises a CCL18 antigen, a C1D antigen, an FXR1 antigen, a ZNF573 antigen, an ESO1 antigen and a p53 antigen or an autoanti...

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Bibliographische Detailangaben
Hauptverfasser:	MO CHUCHAN, HUANG CHAOYUAN, CHEN JIAWEN, LIN DANG, LI HONGFENG, LIU ZIYING, ZHOU LAMEI, WANG XINGYONG, ZHAO FENG, WANG ZENGSONG, HU HAI, HUANG LU, LIAO LIYING, QIN WEIWEN
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING PHYSICS TESTING
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Beschreibung
Zusammenfassung:	The invention discloses a biomarker combination, a diagnostic kit containing the biomarker combination and application of the biomarker combination. The biomarker combination comprises a CCL18 antigen, a C1D antigen, an FXR1 antigen, a ZNF573 antigen, an ESO1 antigen and a p53 antigen or an autoantibody combined with the antigens. And the biomarker further comprises one or more antigens selected from the group consisting of CA125, TM4SF1, IGFBP1, FUBP1, ARP3, KRAS, SPINT1 and YKL-40, or an autoantibody combined with the antigens. The diagnostic kit comprises the biomarker combination, shows excellent diagnostic performance on ovarian cancer, and can be used for diagnosis or auxiliary diagnosis of early ovarian cancer, or used for relapse monitoring and prognosis monitoring after ovarian cancer treatment. 本发明公开了一种生物标志物组合、含其的诊断试剂盒及其应用。所述生物标志物组合包含CCL18、C1D、FXR1、ZNF573、ESO1和p53抗原或结合其的自身抗体；且所述生物标志物还包含选自：CA125、TM4SF1、IGFBP1、FUBP1、ARP3、KRAS、SPINT1和YKL-40中的一种或多种的抗原或结合其的自身抗体。所述诊断试剂盒包括所述生物标志物组合，其显示出对卵巢癌优良的诊断性能，可用于诊断或辅助