Method for preparing ticagrelor high-grade intermediate through continuous flow reaction

The invention discloses a method for preparing a ticagrelor high-grade intermediate through continuous flow reaction, which comprises the following steps: dissolving a raw material 1 in an organic solvent, uniformly stirring to obtain a material A, metering and conveying the material A and a diazoti...

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Hauptverfasser: GAO CHENWEI, YU ZHIQUN, ZHOU JIADI
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses a method for preparing a ticagrelor high-grade intermediate through continuous flow reaction, which comprises the following steps: dissolving a raw material 1 in an organic solvent, uniformly stirring to obtain a material A, metering and conveying the material A and a diazotization reagent into a mixer through a metering pump respectively, and quickly mixing to obtain a material B; the method comprises the following steps: adding a cation exchange resin into a tubular reactor, uniformly mixing, adding a uniformly mixed material into the tubular reactor filled with solid acid, carrying out a diazotization-coupling reaction, and after the reaction is finished, recovering a solvent from an organic liquid phase after the reaction through distillation to obtain the high-grade intermediate of ticagrelor. The method has the advantages of easiness in separation, mild reaction conditions, no equipment corrosion and the like, can be recycled without being regenerated by an acid solution under a