Antiviral prodrugs and uses thereof

The present application relates to a compound of formula (I): # imgabs0 # or a pharmaceutically acceptable salt thereof. These compounds are useful as prodrugs of emtricitabine (FTC) or lamivudine (3TC) for inhibiting viral infections, such as human hepatitis B virus (HBV) infection and human immuno...

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Bibliographische Detailangaben
Hauptverfasser:	HE GONGXIN, WU HAO, HOU KAI
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present application relates to a compound of formula (I): # imgabs0 # or a pharmaceutically acceptable salt thereof. These compounds are useful as prodrugs of emtricitabine (FTC) or lamivudine (3TC) for inhibiting viral infections, such as human hepatitis B virus (HBV) infection and human immunodeficiency virus (HIV) infection. In addition, the present application also relates to pharmaceutical compositions comprising these compounds, and the use of these compounds or pharmaceutical compositions for the prevention and treatment of viral infections in subjects in need thereof. 本申请涉及一种式(I)的化合物：#imgabs0#或其药学上可接受的盐。这些化合物可用作抑制病毒感染诸如人乙型肝炎病毒(HBV)感染和人免疫缺陷病毒(HIV)感染的恩曲他滨(FTC)或拉米夫定(3TC)的前药。此外，本申请还涉及包含这些化合物的药物组合物，以及这些化合物或药物组合物用于预防和治疗有需要的受试者的病毒感染的用途。