Preparation method of dual sustained-release dapagliflozin tablet

The invention relates to a preparation method of a dual sustained-release dapagliflozin tablet, and belongs to the technical field of pharmaceutical preparations. The invention provides a preparation method of a dual sustained-release dapagliflozin tablet, the dapagliflozin tablet is composed of an...

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Hauptverfasser: SHI LIPING, JIANG NANSHAN, YIN QIANG, ZHANG WEIBING, TONG HAO
Format: Patent
Sprache:chi ; eng
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Beschreibung
Zusammenfassung:The invention relates to a preparation method of a dual sustained-release dapagliflozin tablet, and belongs to the technical field of pharmaceutical preparations. The invention provides a preparation method of a dual sustained-release dapagliflozin tablet, the dapagliflozin tablet is composed of an enteric inner core, a gastric-soluble middle core and a coating, the gastric-soluble middle core is composed of the following raw and auxiliary materials by weight: 5-7% of dapagliflozin, 10% of voglibose, 69-73% of a microcrystalline cellulose compound, 2-4% of a disintegrating agent, and 10% of an HPMC coating solution, the enteric inner core consists of the following raw and auxiliary materials in percentage by weight: 5-7% of dapagliflozin, 8% of Yuanzheng sugar, 63-77% of a microcrystalline cellulose compound, 4-8% of a disintegrating agent, 8% of an HPMC coating solution and 6% of alginic acid; the capsule has the advantages of high dissolution rate of medicine components, good release effect and small pressu