Establishment and gene transcription regulation analysis of genetic diversity hypertension mouse model

The invention discloses establishment and gene transcription regulation analysis of a genetic diversity hypertension mouse model, and belongs to the technical field of new animal varieties. The establishment of the genetic diversity hypertension mouse model comprises the following steps: hybridizing A/J mice with salt-sensitive hypertension mice with the genotype of Cckbr to obtain F1-generation mice, and mating the mice with the genotype of Cckbr < +/-> in the F1-generation mice with the mice with the genotype of Cckbr < +/-> in the same nest to obtain the genetic diversity hypertension mouse model. The mice with the genotype of Cckbr in the obtained F2-generation mice are the genetic diversity hypertension mouse model. 本发明公开了遗传多样性高血压小鼠模型的建立与基因转录调控分析，属于动物新品种技术领域。前述遗传多样性高血压小鼠模型的建立包括如下步骤：将A/J小鼠与基因型为Cckbr-/-的盐敏感性高血压小鼠进行杂交，得到F1代小鼠，将F1代小鼠中基因型为Cckbr+/-的小鼠与其同窝的基因型为Cckbr+/-的小鼠进行交配，得到的F2代小鼠中基因型为Cckbr-/-的小鼠即为遗传多样性高血压小鼠模型。