Compositions and formulations for topical use of AKT inhibitors for prevention, treatment and amelioration of skin diseases, conditions and disorders

Provided herein is a composition comprising a compound having the structure: (1H tautomer) and/or (2H tautomer) pharmaceutically acceptable salts thereof, and one or more excipients selected from (a)-(g): a) a C2-6 alcohol; b) an organic solvent and/or a penetration promoter; c) an antioxidant; d) a preservative; e) water; f) a pH adjusting agent; and g) a gelling agent, wherein the C2-6 alcohol, the organic solvent and/or the penetration enhancer, the antioxidant, the preservative, the water, the pH adjusting agent and the gelling agent are defined and described herein. Also provided herein are methods of treating skin diseases, conditions, or disorders, particularly seborrheic keratosis, using the compositions. # imgabs0 # (1H tautomer) and/or # imgabs1 # (2H tautomer). 本文提供了一种组合物，其包含具有以下结构的化合物：(1H互变异构体)和/或(2H互变异构体)其药学上可接受的盐，以及选自(a)-(g)的一种或多种赋形剂：a)C2-6醇；b)有机溶剂和/或穿透促进剂；c)抗氧化剂；d)防腐剂；e)水；f)pH调节剂；以及g)胶凝剂，其中C2-6醇、有机溶剂和/或穿透促进剂、抗氧化剂、防腐剂、水、pH调节剂和胶凝剂在本文定义和描述。本文还提供了使用组合物治疗皮肤疾病、病况或病症，特别是脂溢性角化病的方法。#imgabs0#(1H互变异构体)和/或