Nucleoside triphosphate synthetic bulk drug and preparation method thereof

The invention discloses a nucleoside triphosphate synthesis bulk drug and a preparation method thereof, and relates to the technical field of chemical synthesis. The preparation method for synthesizing the raw material medicine comprises the following steps: adding p-hydroxybenzyl alcohol, triethylamine and DMAP into an organic solvent, stirring and dissolving, and cooling in an ice salt bath; slowly dropwise adding an acylation reagent, heating the reaction system to room temperature after dropwise adding, and continuing the reaction; after the reaction is finished, adding water for washing, standing for layering, extracting a water layer with an organic solvent, merging into an organic layer, washing the organic layer with water again, and then adding a drying agent for drying; filtering to remove the drying agent, taking filtrate, adding silica gel to make sand, loading on a column for column chromatography to obtain colorless liquid, and cooling to obtain white solid. The method has the advantages that th