Continuous production device and method of meropenem mother nucleus intermediate
The invention relates to a continuous production device and method for a meropenem mother nucleus intermediate, and belongs to the technical field of green synthesis of heterocyclic compounds, and the continuous production method is characterized in that 4-AA and bromine spiro ring are used as start...
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Format: | Patent |
Sprache: | chi ; eng |
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Zusammenfassung: | The invention relates to a continuous production device and method for a meropenem mother nucleus intermediate, and belongs to the technical field of green synthesis of heterocyclic compounds, and the continuous production method is characterized in that 4-AA and bromine spiro ring are used as starting materials and continuously enter a fluidized bed reactor filled with zinc powder and a catalyst for a Reformatsky reaction, then washing is performed to obtain a mother nucleus intermediate solution of a penem drug, and the mother nucleus intermediate solution is subjected to a continuous reaction to obtain the meropenem drug. The method is used for next-step synthesis of the penem drug mother nucleus 4-BMA, and continuous production of the penem drug mother nucleus intermediate is achieved. The method disclosed by the invention has the advantages of good heat and mass transfer effects, short reaction time, high safety coefficient, high product yield, high product quality and the like, and the production cost o |
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