Tissue adhesion type ICG-particle gel material for colorectal cancer postoperative treatment and application of tissue adhesion type ICG-particle gel material

The invention relates to a tissue adhesion type ICG-particle gel material for colorectal cancer postoperative treatment and application of the tissue adhesion type ICG-particle gel material. The particle gel material has good biodegradability, biocompatibility and photo-thermal performance, the body...

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Hauptverfasser: ZHANG KUNXI, DENG WANLI, LI YUE, WANG JIE, YIN PEIHAO, YUAN ZETING, SHANG JING, CHEN JIA, WANG LU, LI ZONGHENG, CHEN TENG, RUI YUANPENG, XIA QI
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention relates to a tissue adhesion type ICG-particle gel material for colorectal cancer postoperative treatment and application of the tissue adhesion type ICG-particle gel material. The particle gel material has good biodegradability, biocompatibility and photo-thermal performance, the body immunity can be effectively activated by combining photo-thermal therapy mediated by the particle gel material with an immune checkpoint inhibitor aPD-L1, postoperative recurrence and metastasis of colon cancer are inhibited, and the particle gel material has wide clinical application prospects. 本发明涉及一种用于结直肠癌术后治疗的组织粘附型ICG-颗粒凝胶材料及其应用。本发明的颗粒凝胶材料具有良好的生物降解性、生物相容性和光热性能,其介导的光热治疗联合免疫检查点抑制剂aPD-L1可有效激活机体免疫,抑制结肠癌术后复发与转移,具有广阔的临床应用前景。