Microsphere as well as preparation method and application thereof

The invention belongs to the technical field of biological medicines, and discloses microspheres as well as a preparation method and application thereof. The microsphere is prepared from the following raw materials: a polyester high polymer material, carboxymethyl cellulose, sodium alginate, beta-glucose, silk fibroin and a solvent. The raw materials contain carboxymethyl cellulose, sodium alginate, beta-glucose and silk fibroin, through reasonable matching and combined action of the raw materials, a protective film can be formed on the surface of the microsphere, the microsphere is prevented from being softened and deformed in the spray drying process, the microsphere can keep a stable degradation rate, and the injection requirement is met. 本发明属于生物医药技术领域，公开了一种微球及其制备方法和应用。本发明微球包括以下原料：聚酯类高分子材料、羧甲基纤维素、海藻酸钠、β-葡萄糖、丝素蛋白和溶剂。本发明的原料中含有羧甲基纤维素、海藻酸钠、β-葡萄糖和丝素蛋白，通过这些原料合理搭配，共同作用，可在微球表面形成保护膜，防止喷雾干燥过程中微球软化变形，且使得微球能够保持稳定的降解速率，满足注射需求。