Fully human-derived antagonistic antibody taking PARP9 protein as target spot and application of fully human-derived antagonistic antibody

The invention belongs to the technical field of gene engineering and protein engineering, and particularly relates to a fully human antagonistic antibody taking PARP9 protein as a target spot and application of the fully human antagonistic antibody. According to the present invention, the completely humanized antagonistic antibody using the PARP9 protein as the target spot is screened from the human scFv phage antibody library, the amino acid sequence of the completely humanized antagonistic antibody is represented by SEQ ID NO: 1 or SEQ ID NO: 2, and the completely humanized antagonistic antibody has the PARP9 protein targeting specificity, and has the application prospect in preparation of the product for diagnosis, treatment or alleviation of the primary sicca syndrome. 本发明属于基因工程和蛋白质工程技术领域，具体涉及一种以PARP9蛋白为靶点的全人源拮抗抗体及其应用。本发明从人scFv噬菌体抗体库筛选以PARP9蛋白为靶点的全人源拮抗抗体，其氨基酸序列为如SEQ ID NO:1或SEQ ID NO:2所示，该全人源拮抗抗体具有靶向PARP9蛋白的特异性，具有制备诊断、治疗或缓解原发性干燥综合征产品的应用前景。