Antibacterial peptide KW13 and application thereof

The invention belongs to the technical field of biological medicines, and particularly relates to an antibacterial peptide KW13 and application thereof. The invention discloses the antibacterial peptide KW13 or the salt thereof for the first time, the antibacterial peptide KW13 has strong antibacterial activity on standard strains and clinical drug-resistant strains, the bactericidal speed is equivalent to that of polymyxin E, but the bactericidal effect lasts longer. In addition, the antibacterial peptide KW13 has the characteristics of low hemolytic activity, low bacterial drug resistance and high stability in plasma, and can significantly reduce the bacterial load of mouse lungs in a mouse pneumonia model. 本发明属于生物医药技术领域，具体涉及一种抗菌肽KW13及其应用。本发明首次公开了抗菌肽KW13或其盐，该抗菌肽KW13对标准菌株和临床耐药菌株具有强抗菌活性，并且杀菌速度与多粘菌素E相当，但杀菌作用持续时间更长。此外，抗菌肽KW13具有溶血活性低、细菌耐药性低和血浆中稳定性较高的特性，在小鼠肺炎模型中能够显著减少鼠肺的细菌载荷。