Hydrogel with oxidation-reduction sensitivity and biological activity as well as preparation method and application thereof

The invention provides hydrogel with oxidation-reduction sensitivity and biological activity as well as a preparation method and application of the hydrogel. The redox sensitive bioactive hydrogel disclosed by the invention can realize effective delivery of stem cells and local controlled release of PRP growth factors, regulate an intimal microenvironment, prevent mouse endometrium adhesion and accelerate repair of damaged intimal. The hydrogel prepared from the natural biomacromolecules tChi and tHA modified by sulfydryl has the advantages of no immunogenicity, biodegradability, high biological activity and the like. Compared with the existing commercialized sodium hyaluronate hydrogel (G-HA) for clinically treating intrauterine adhesion, the bioactive hydrogel prepared by the invention shows more excellent endometrial repair promoting capability in animal experiments. 本发明提供了一种具有氧化还原敏感性和生物活性的水凝胶及其制备方法与应用。本发明的氧化还原敏感性生物活性水凝胶可实现干细胞有效递送和PRP生长因子的局部控释，调节内膜微环境，防止小鼠子宫内膜粘连并加速损伤内膜的修复。采用经巯基改性修饰的天然生物大分子tChi和tHA制备的水凝胶具有无