Peptide and protein interaction and corresponding binding residue prediction method and system

The invention discloses a prediction method for peptide-protein interaction and corresponding binding residues. The prediction method comprises the following steps: acquiring peptide-protein interaction and corresponding interaction site information, and constructing a data set; calculating the mult...

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Bibliographische Detailangaben
Hauptverfasser: ZHAO HAOCHEN, WANG JIANXIN, ZHOU RUIKANG, DUAN GUIHUA
Format: Patent
Sprache:chi ; eng
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Beschreibung
Zusammenfassung:The invention discloses a prediction method for peptide-protein interaction and corresponding binding residues. The prediction method comprises the following steps: acquiring peptide-protein interaction and corresponding interaction site information, and constructing a data set; calculating the multi-source sequence characteristics of the peptide and the protein; constructing peptide residue features, protein residue features, peptide sequence features and protein sequence features, and mapping the features to a unified feature dimension space to obtain corresponding feature vectors; constructing a peptide-protein pair interaction diagram; constructing a peptide and protein interaction and corresponding binding site prediction model, and training; and adopting the trained peptide and protein interaction and corresponding binding site prediction model to predict the actual peptide-protein interaction result and the interaction residue site. The invention also discloses a system for realizing the method for pre