Construction method of uveal melanoma patient prognosis condition calculation and analysis model

The invention discloses a construction method of a uveal melanoma patient prognosis condition calculation and analysis model. The construction method comprises the following steps: S1, extracting features through a patient pathology image to generate first omics data; s2, placing the transcriptome i...

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Hauptverfasser: WANG YING, TANG MOSHENG, YU DIYANG, SHI YUTAO, WEI LIHAN, HONG BOXIANG, FU HAN, LIN JIAYI, WANG LIHUA, WANG HUAFU, CHEN TONGKE
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses a construction method of a uveal melanoma patient prognosis condition calculation and analysis model. The construction method comprises the following steps: S1, extracting features through a patient pathology image to generate first omics data; s2, placing the transcriptome information of the patient into a self-regularization network for processing to obtain second omics data; s3, fusing the first omics data and the second omics data through a gating-based attention mechanism and a Kronecker product to generate a prediction model; s4, training of the whole prediction model is supervised through a loss function based on a negative log-likelihood function; s5, generating corresponding attribution data from the patient features through an integral gradient algorithm; and S6, inputting the features of the to-be-predicted patient into the prediction model, and obtaining a risk coefficient value of the to-be-predicted patient by the prediction model so as to judge whether the to-be-predicte