Probe combination, kit and method for detecting genetic susceptibility gene of melanoma
The invention discloses a probe combination for detecting genetic susceptibility genes of melanoma. The probe combination comprises at least one of sequences as shown in SEQ ID NO.1-445. The invention also discloses a kit comprising the probe combination and a method for detecting the genetic suscep...
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| creator | YU KE HE PENGHAI LIN XIAOJIAN MA YINI HU YAOWEN DING LINFENG |
| description | The invention discloses a probe combination for detecting genetic susceptibility genes of melanoma. The probe combination comprises at least one of sequences as shown in SEQ ID NO.1-445. The invention also discloses a kit comprising the probe combination and a method for detecting the genetic susceptibility gene of melanoma by using the kit. According to the invention, melanoma genetic susceptibility related genes BAP1, BRCA2, CDK4, CDKN2A, NF1, PALB2, PTEN, TERT, STK11 and MBD4 can be detected at one time by using a hybrid capture method. The probe is wide in coverage, high in sequencing depth and capable of detecting embryonic line variation of all exon regions of a target gene. According to the invention, all related diseases of melanoma genetic susceptibility related genes can be reported, and genetic modes corresponding to the diseases are provided.
本发明公开了一种检测黑色素瘤遗传易感基因的探针组合，包括SEQ ID NO.1～445所示序列中的至少一种。并公开了包括所述探针组合的试剂盒以及利用所述试剂盒检测黑色素瘤遗传易感基因的方法。本发明利用杂交捕获法可以一次性检测黑色素瘤遗传易感相关基因BAP1、BRCA2、CDK4、CDKN2A、NF1、PALB2、 |
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本发明公开了一种检测黑色素瘤遗传易感基因的探针组合，包括SEQ ID NO.1～445所示序列中的至少一种。并公开了包括所述探针组合的试剂盒以及利用所述试剂盒检测黑色素瘤遗传易感基因的方法。本发明利用杂交捕获法可以一次性检测黑色素瘤遗传易感相关基因BAP1、BRCA2、CDK4、CDKN2A、NF1、PALB2、</description><language>chi ; eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS OR TEST PAPERS THEREFOR ; COMPOSITIONS THEREOF ; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ; CULTURE MEDIA ; ENZYMOLOGY ; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; PROCESSES OF PREPARING SUCH COMPOSITIONS ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240604&DB=EPODOC&CC=CN&NR=118127155A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76516</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240604&DB=EPODOC&CC=CN&NR=118127155A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>YU KE</creatorcontrib><creatorcontrib>HE PENGHAI</creatorcontrib><creatorcontrib>LIN XIAOJIAN</creatorcontrib><creatorcontrib>MA YINI</creatorcontrib><creatorcontrib>HU YAOWEN</creatorcontrib><creatorcontrib>DING LINFENG</creatorcontrib><title>Probe combination, kit and method for detecting genetic susceptibility gene of melanoma</title><description>The invention discloses a probe combination for detecting genetic susceptibility genes of melanoma. The probe combination comprises at least one of sequences as shown in SEQ ID NO.1-445. The invention also discloses a kit comprising the probe combination and a method for detecting the genetic susceptibility gene of melanoma by using the kit. According to the invention, melanoma genetic susceptibility related genes BAP1, BRCA2, CDK4, CDKN2A, NF1, PALB2, PTEN, TERT, STK11 and MBD4 can be detected at one time by using a hybrid capture method. The probe is wide in coverage, high in sequencing depth and capable of detecting embryonic line variation of all exon regions of a target gene. According to the invention, all related diseases of melanoma genetic susceptibility related genes can be reported, and genetic modes corresponding to the diseases are provided.
本发明公开了一种检测黑色素瘤遗传易感基因的探针组合，包括SEQ ID NO.1～445所示序列中的至少一种。并公开了包括所述探针组合的试剂盒以及利用所述试剂盒检测黑色素瘤遗传易感基因的方法。本发明利用杂交捕获法可以一次性检测黑色素瘤遗传易感相关基因BAP1、BRCA2、CDK4、CDKN2A、NF1、PALB2、</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS OR TEST PAPERS THEREFOR</subject><subject>COMPOSITIONS THEREOF</subject><subject>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PROCESSES OF PREPARING SUCH COMPOSITIONS</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjLsKAjEQRdNYiPoPY69FlEVbWRQrsRAslzwm62CSCZux8O994AdYXTicc8fqeh7YIjhOlrIR4ryAOwmY7CGh3NhD4AE8Cjqh3EOPGYUc1Ed1WIQsRZLnFwOHdxNN5mSmahRMrDj77UTND_tLe1xi4Q5rMe7z07Unrbd6tdFNs1v_47wAUVc55w</recordid><startdate>20240604</startdate><enddate>20240604</enddate><creator>YU KE</creator><creator>HE PENGHAI</creator><creator>LIN XIAOJIAN</creator><creator>MA YINI</creator><creator>HU YAOWEN</creator><creator>DING LINFENG</creator><scope>EVB</scope></search><sort><creationdate>20240604</creationdate><title>Probe combination, kit and method for detecting genetic susceptibility gene of melanoma</title><author>YU KE ; HE PENGHAI ; LIN XIAOJIAN ; MA YINI ; HU YAOWEN ; DING LINFENG</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN118127155A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2024</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS OR TEST PAPERS THEREFOR</topic><topic>COMPOSITIONS THEREOF</topic><topic>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PROCESSES OF PREPARING SUCH COMPOSITIONS</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>YU KE</creatorcontrib><creatorcontrib>HE PENGHAI</creatorcontrib><creatorcontrib>LIN XIAOJIAN</creatorcontrib><creatorcontrib>MA YINI</creatorcontrib><creatorcontrib>HU YAOWEN</creatorcontrib><creatorcontrib>DING LINFENG</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>YU KE</au><au>HE PENGHAI</au><au>LIN XIAOJIAN</au><au>MA YINI</au><au>HU YAOWEN</au><au>DING LINFENG</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Probe combination, kit and method for detecting genetic susceptibility gene of melanoma</title><date>2024-06-04</date><risdate>2024</risdate><abstract>The invention discloses a probe combination for detecting genetic susceptibility genes of melanoma. The probe combination comprises at least one of sequences as shown in SEQ ID NO.1-445. The invention also discloses a kit comprising the probe combination and a method for detecting the genetic susceptibility gene of melanoma by using the kit. According to the invention, melanoma genetic susceptibility related genes BAP1, BRCA2, CDK4, CDKN2A, NF1, PALB2, PTEN, TERT, STK11 and MBD4 can be detected at one time by using a hybrid capture method. The probe is wide in coverage, high in sequencing depth and capable of detecting embryonic line variation of all exon regions of a target gene. According to the invention, all related diseases of melanoma genetic susceptibility related genes can be reported, and genetic modes corresponding to the diseases are provided.
本发明公开了一种检测黑色素瘤遗传易感基因的探针组合，包括SEQ ID NO.1～445所示序列中的至少一种。并公开了包括所述探针组合的试剂盒以及利用所述试剂盒检测黑色素瘤遗传易感基因的方法。本发明利用杂交捕获法可以一次性检测黑色素瘤遗传易感相关基因BAP1、BRCA2、CDK4、CDKN2A、NF1、PALB2、</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE |
| title | Probe combination, kit and method for detecting genetic susceptibility gene of melanoma |
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