Probe combination, kit and method for detecting genetic susceptibility gene of melanoma

The invention discloses a probe combination for detecting genetic susceptibility genes of melanoma. The probe combination comprises at least one of sequences as shown in SEQ ID NO.1-445. The invention also discloses a kit comprising the probe combination and a method for detecting the genetic susceptibility gene of melanoma by using the kit. According to the invention, melanoma genetic susceptibility related genes BAP1, BRCA2, CDK4, CDKN2A, NF1, PALB2, PTEN, TERT, STK11 and MBD4 can be detected at one time by using a hybrid capture method. The probe is wide in coverage, high in sequencing depth and capable of detecting embryonic line variation of all exon regions of a target gene. According to the invention, all related diseases of melanoma genetic susceptibility related genes can be reported, and genetic modes corresponding to the diseases are provided. 本发明公开了一种检测黑色素瘤遗传易感基因的探针组合，包括SEQ ID NO.1～445所示序列中的至少一种。并公开了包括所述探针组合的试剂盒以及利用所述试剂盒检测黑色素瘤遗传易感基因的方法。本发明利用杂交捕获法可以一次性检测黑色素瘤遗传易感相关基因BAP1、BRCA2、CDK4、CDKN2A、NF1、PALB2、