DSC2 binding protein, preparation method and application

The invention provides a DSC2 binding protein as well as a preparation method and application thereof, and relates to the technical field of antibodies. The DSC2 binding protein comprises a light chain variable region and a heavy chain variable region, the VH-CDR1 is as shown in SEQ ID NO.1, the VH-CDR2 is as shown in SEQ ID NO.2, and the VH-CDR3 is as shown in SEQ ID NO.3; the amino acid sequence of the VL-CDR1 is as shown in SEQ ID NO.4, the amino acid sequence of the VL-CDR2 is as shown in SEQ ID NO.5, and the amino acid sequence of the VL-CDR3 is as shown in SEQ ID NO.6. The binding protein has good specific binding capacity with DSC2, and can be used for identification of DSC2 antigen and diagnosis and detection of DSC2 related diseases. 本发明提供了一种DSC2结合蛋白、制备方法和应用，涉及抗体技术领域。DSC2结合蛋白包含轻链可变区和重链可变区，其中VH-CDR1如SEQ ID NO.1所示，VH-CDR2如SEQ ID NO.2所示，VH-CDR3如SEQ ID NO.3所示；VL-CDR1的氨基酸序列如SEQ ID NO.4所示，VL-CDR2的氨基酸序列如SEQ ID NO.5所示，VL-CDR3的氨基酸序列如SEQ ID NO.6所示。该结合蛋白与DSC2具有良好的特异性结合能力，可用于DSC2抗原的鉴定和DSC2相关疾病的诊断检测。