Synthesis method of 1-(2-methoxyphenyl) piperazine hydrochloride

The invention discloses a synthesis method of 1-(2-methoxyphenyl) piperazine hydrochloride, which comprises the following steps: (1) carrying out chlorination reaction by taking diethanol amine as a basic raw material and thionyl chloride as a chlorinating agent to obtain bis (2-chloroethyl) amine h...

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Bibliographische Detailangaben
Hauptverfasser:	CHEN WEI, WANG JING, ZHANG DUILIANG, LUO JIE, WANG QI, ZHANG SONG, WEI JINZHE, PENG YUE, XU WEIGUO, LIANG JIAO
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:	The invention discloses a synthesis method of 1-(2-methoxyphenyl) piperazine hydrochloride, which comprises the following steps: (1) carrying out chlorination reaction by taking diethanol amine as a basic raw material and thionyl chloride as a chlorinating agent to obtain bis (2-chloroethyl) amine hydrochloride; and (2) carrying out Boc group protection on bis (2-chloroethyl) amine, carrying out a ring formation condensation reaction on bis (2-chloroethyl) amine and o-methoxyaniline, removing a Boc protecting group to obtain 1-(2-methoxyphenyl) piperazine, and adding hydrochloric acid to form a salt to obtain the 1-(2-methoxyphenyl) piperazine hydrochloride. The preparation method comprises the following steps: firstly synthesizing bis (2-chloroethyl) amine hydrochloride by taking diethanol amine as a basic raw material and thionyl chloride as a chlorinating agent, then carrying out Boc group protection on bis (2-chloroethyl) amine, then carrying out cyclization condensation reaction on bis (2-chloroethyl) am