Preparation method of furovatriptan degradation impurity and application of furovatriptan degradation impurity

The invention relates to the field of drug impurity detection, in particular to a preparation method of a furovatriptan degradation impurity and application of the furovatriptan degradation impurity. The preparation method of the furovatriptan degradation impurity comprises the following steps: S1, substitution reaction of a compound 2; s2, carrying out alkaline hydrolysis reaction on the compound 3; and S3, recrystallizing and refining, wherein the compound 2 is frovatriptan succinate. The invention provides the preparation method of the furovatriptan degradation impurity for the first time, and the obtained degradation impurity can be effectively applied to preparation of a reference substance of the furovatriptan degradation impurity, and is of great significance in improving the quality level of a furovatriptan raw material medicine and a preparation of the furovatriptan raw material medicine. 本发明涉及药物杂质检测领域，尤其涉及一种呋罗曲坦降解杂质的制备方法及其所得物应用。呋罗曲坦降解杂质的制备方法包括以下步骤：S1：化合物2的取代反应；S2：化合物3的碱性水解反应；S3：重结晶精制，其中化合物2为琥珀酸呋罗曲坦。