Application of hsacirc0066187 in preparation of sepsis detection kit and sepsis treatment medicine

The invention relates to application of hsacirc0066187 in preparation of a sepsis detection kit and a sepsis treatment drug, and relates to the technical field of biomedicine. The invention discovers that the hsacirc0066187 is highly expressed in a human vascular endothelial cell stimulated by lipopolysaccharide (LPS), and the expression of inflammatory factors IL-1beta and IL-6 can be reduced and the expression of tight junction proteins Occludin and ZO-1 can be improved by knocking down the circRNA. The hsacirc0066187 regulates the activity of a downstream RhoA/ROCK1 signal channel by regulating and controlling miRNA-185-5p, finally, the expression difference of the hsacirc0066187 in peripheral blood of sepsis patients and healthy control people is shown, the expression quantity of the hsacirc0066187 is remarkably related to disease severity and overall prognosis, and the hsacirc0066187 can be used as a key target for sepsis detection and treatment. 本发明涉及hsa_circ_0066187在制备脓毒症检测试剂盒和治疗药物中的应用，涉及生物医学技术领域。本发明发现