Methods of treating substance abuse

The present disclosure relates to methods of treating substance abuse. Specifically, provided is a method of treating a substance use disorder in a subject comprising administering to the subject a therapeutically effective amount of a composition comprising R (-)-ketamine or a pharmaceutically acceptable salt thereof wherein the composition is substantially free of S (+)-ketamine or a pharmaceutically acceptable salt thereof. 本公开涉及治疗物质滥用的方法。具体地，提供了治疗受试者中的物质使用障碍的方法，其包括向所述受试者施用治疗有效量的包含R(-)-氯胺酮或其药学上可接受的盐的组合物，其中所述组合物基本上不含S(+)-氯胺酮或其药学上可接受的盐。