Compositions and methods of mRNA vaccines against novel coronavirus infection

Provided herein is a ribonucleic acid (RNA) encoding a spike (S) protein of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), or an immunogenic fragment thereof, the spike (S) protein or the immunogenic fragment thereof comprising at least one non-naturally occurring amino acid mutation....

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Hauptverfasser:	ANANTHASWAMY NITHSH, SHEN DONG, BROWN DAVID, JEON JOO-HYUNG, LU CHUN, TANG SHENGGAO, BONG, YOUNG-SIK, HE JIAXI, CHEN RENXIANG, HE ZIYANG, LONG ZHIFENG, LU, PATRICK, Y
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CALCULATING CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPUTING CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES COUNTING ELECTRIC DIGITAL DATA PROCESSING ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Provided herein is a ribonucleic acid (RNA) encoding a spike (S) protein of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), or an immunogenic fragment thereof, the spike (S) protein or the immunogenic fragment thereof comprising at least one non-naturally occurring amino acid mutation. In some embodiments, the S protein is derived from a delta variant. Related polynucleotides, vectors, cells, compositions, kits, methods of production, and methods of use are also provided. 本文提供了编码严重急性呼吸综合征冠状病毒2(SARS-CoV-2)的刺突(S)蛋白或其免疫原性片段的核糖核酸(RNA)，该刺突(S)蛋白或其免疫原性片段包含至少一个非天然存在的氨基酸突变。在一些实施方案中，该S蛋白来源于δ变体。另外提供了相关的多核苷酸、载体、细胞、组合物、试剂盒、生产方法和使用方法。