FC variants with high thermal stability and attenuated effector function

A polypeptide comprising one or more variant Fc regions, each of the variant Fc regions comprising two CH2 domains, where at least one CH2 domain in at least one of the variant Fc regions is a variant CH2 domain, and where the amino acid residues at positions 234, 235 and 265 (all positions are repr...

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Bibliographische Detailangaben
Hauptverfasser:	NAGAOKA NOBUMI, MAKINO TOMOHIRO, SHINOZAKI NAOYA
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	A polypeptide comprising one or more variant Fc regions, each of the variant Fc regions comprising two CH2 domains, where at least one CH2 domain in at least one of the variant Fc regions is a variant CH2 domain, and where the amino acid residues at positions 234, 235 and 265 (all positions are represented by EU numbering) of the variant CH2 domain are Ala, Ala and Gly, or Ala, Ala and Asn, respectively. 一种包含一个或多个变体Fc区的多肽，所述变体Fc区中的每一个包含两个CH2结构域，其中至少一个所述变体Fc区中的至少一个CH2结构域是变体CH2结构域，并且其中所述变体CH2结构域的位置234、235和265(所有位置均由EU编号表示)处的氨基酸残基分别是Ala、Ala和Gly，或Ala、Ala和Asn。