Long-acting amylin-like polypeptide derivative as well as preparation method and application thereof

The invention discloses a long-acting amylin-like polypeptide derivative or salt thereof and a preparation method and application thereof, the polypeptide derivative is shown as a formula (I), the first amino acid Lys at the N end in a main peptide chain has and only has an amide formed by connecting a branched chain Z shown as a formula (II), and the group definition is detailed in the specification. The polypeptide derivative compound and the pharmaceutically acceptable salt thereof provided by the invention can be used for treating metabolic related diseases such as diabetes mellitus and obesity. # imgabs0 # 本发明公开了一种长效的类似胰淀素的多肽衍生物或其盐及其制备方法和用途，其中，所述多肽衍生物如式(Ⅰ)所示，主肽链中N端首位氨基酸Lys有且仅有一个连接式(II)所示支链Z形成的酰胺，其中基团定义详见说明书。本发明提供的多肽衍生化合物及其药学上可接受的盐可用于治疗糖尿病、肥胖等代谢性相关疾病。#imgabs0#