Industrial refining and purifying method of vocyclosporine precursor

The invention provides an industrial refining and purifying method of a vocyclosporine precursor isomer, and relates to the field of drug synthesis, a special solvent system is adopted to purify and refine a vocyclosporine precursor, the vocyclosporine precursor isomer impurity is effectively removed, and finally the vocyclosporine precursor with high purity and low content of isomer impurity is obtained. The vocyclosporine precursor purified by the method disclosed by the invention is used for preparing and synthesizing the vocyclosporine, the purity is high, and the content of an isomer is within a control standard range. The chromatographic column purification step in the traditional process of the vocyclosporine is simplified, the operation is simple, the production cost is low, and the industrial popularization is easy. 本发明提供一种伏环孢素前体异构体的工业化精制纯化方法，涉及药物合成领域，本发明采用特殊的溶剂体系对伏环孢素前体进行纯化精制，有效去除伏环孢素前体异构体杂质，最终获得纯度高、异构体杂质含量低的伏环孢素前体，利用本发明方法纯化后伏环孢素前体制备合成伏环孢素，纯度高，异构体含量在控制标准范围内。简化了伏环孢素传统工艺中的层析柱纯化步骤，操作简单，生产成本低，易于工业化推广。