Chlorella oligopeptide for reducing blood pressure and composition and application thereof

The invention relates to the technical field of biology, and particularly discloses a series of high-activity ACE (angiotensin converting enzyme) inhibitory peptides or derivatives which are obtained by taking chlorella as a raw material through separation, purification and structure optimization, and the series of high-activity ACE inhibitory peptides or derivatives are used for developing functional foods, health-care products or medicines for reducing blood pressure. Chlorella is subjected to ultrasonic treatment and protease enzymolysis to obtain a chlorella proteolysis peptide crude extract, and the chlorella pentapeptide Leu-Val-Ala-Lys-Ala is obtained through Sephadex G15 gel chromatography, Sepharose DEAE fast flow anion exchange chromatography and C18 reversed-phase chromatography separation, and IC50 is 26.66 [mu] M. LVAKA is taken as a template, a series of chlorella oligopeptides with high ACE inhibitory activity are obtained through single/multi-amino acid mutation or shortening of the sequence l