Drug-resistant bacterium biofilm inhibitor and development method thereof

The invention discloses a drug-resistant bacterium biofilm inhibitor and a development method thereof, and relates to the technical field of calf source escherichia coli treatment, and the drug-resistant bacterium biofilm inhibitor comprises the following components: berberine and minocycline; a biofilm for inhibition of the inhibitor is a calf source Escherichia coli biofilm, and berberine and minocycline are combined for use. According to the drug-resistant bacterium biofilm inhibitor and the application thereof, when the inhibitor composed of berberine and minocycline is used, the adhesion value of a biofilm strong positive strain can be remarkably or extremely remarkably reduced, the growth and formation of the strain biofilm can be reduced, the generation of a calf source escherichia coli biofilm can be jointly reduced, the drug resistance of the strain can be further reduced, and the drug resistance of the strain can be further reduced. And diseases caused by repeated and persistent infection after the