Transdermal drug delivery microneedle for treating tinea pedis as well as preparation method and application of transdermal drug delivery microneedle
The invention belongs to the technical field of biological medicines, and relates to a transdermal drug delivery microneedle for treating tinea pedis as well as a preparation method and application of the transdermal drug delivery microneedle. The antibacterial peptide FK13-a1, the salicylic acid SA...
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Format: | Patent |
Sprache: | chi ; eng |
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Zusammenfassung: | The invention belongs to the technical field of biological medicines, and relates to a transdermal drug delivery microneedle for treating tinea pedis as well as a preparation method and application of the transdermal drug delivery microneedle. The antibacterial peptide FK13-a1, the salicylic acid SA and the methacrylated gelatin GelMA are used as main components, and the transdermal drug delivery microneedle with the needle tip having enough penetrating power and the flexible substrate is prepared. The microneedle platform can be attached to the affected part of tinea pedis, salicylic acid SA is released to soften cutin and then antibacterial peptide FK13-a1 is released according to the degradation speed difference of the tip and the substrate of the microneedle, the softened cutin promotes further diffusion of the antibacterial peptide FK13-a1, pathogenic bacteria deep in the skin can be killed, and the effect of treating tinea pedis is achieved. When tinea pedis is serious, the GelMA MNs can be promoted to |
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