Novel photosensitizer for overcoming tumor hypoxia as well as preparation method and application of novel photosensitizer

The invention relates to a novel photosensitizer for overcoming tumor hypoxia and a preparation method and application thereof.The structure of the photosensitizer is shown in the formula I. The photosensitizer is combined with an alkylating agent aniline nitrogen mustard through a hypoxia-sensitive azobenzene group, an azo bond is broken in a tumor hypoxia area, chemotherapeutic drugs and the photosensitizer are released, and the photosensitizer can be used for treating tumor hypoxia. Therefore, the problems that the photodynamic therapy curative effect of a hypoxia region is insufficient and chemotherapy drugs do not have cell selectivity are solved, the photodynamic therapy and chemotherapy capabilities are achieved, and tests prove that the photodynamic therapy and chemotherapy compound has a good inhibition effect on tumor cells. And the formula I of the # imgabs0 # is shown in the specification. 本发明涉及一种用于克服肿瘤乏氧的新型光敏剂及其制备方法和应用，所述光敏剂的结构如式I所示通过低氧敏感的偶氮苯基团将光敏剂与烷化剂苯胺氮芥结合，在肿瘤低氧区域偶氮键断裂，释放出化疗药与光敏剂，从而解决低氧区域光动力治疗疗