PRMT4 inhibitor as well as pharmaceutical composition, pharmaceutical preparation and application thereof

The invention belongs to the technical field of medicinal chemistry, and relates to a PRMT4 inhibitor as well as a pharmaceutical composition, a pharmaceutical preparation and application thereof. Specifically, the compound disclosed by the invention has a structure as shown in a formula I or a formula II, has excellent in-vitro inhibitory activity on PRMT4, can be used as a PRMT4 small-molecule inhibitor, is used for preventing/treating diseases (such as cancers, inflammatory diseases, autoimmune diseases or diabetes mellitus and the like) which are at least partially mediated by PRMT4, and is used for preparing medicines for preventing/treating the diseases, such as cancer, inflammatory diseases, autoimmune diseases or diabetes mellitus and the like. And the preparation method of the compound is simple and has a good application prospect. # imgabs0 # 本发明属于药物化学技术领域，涉及一种PRMT4抑制剂及其药物组合物、药物制剂和用途。具体而言，本发明的化合物具有如式I或式II所示的结构，针对PRMT4具有优异的体外抑制活性，可以作为PRMT4小分子抑制剂，用于预防/治疗至少部分由PRMT4介导的疾病(如癌症、炎症疾病、自身免疫性疾病或糖尿病等)，以及制备用于预防/