Synthesis method of 7-quaternary carbon substituted dibenzopyran compound

The invention belongs to the technical field of organic synthesis, and particularly relates to a synthesis method of a 7-quaternary carbon substituted dibenzopyran compound. The preparation method comprises the following steps: mixing a 2 '-isopropenyl-1, 1'-biphenyl-2-phenol compound, an...

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Hauptverfasser: ZHOU QIN, ZHAO YUMING, QIAO JINBAO
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention belongs to the technical field of organic synthesis, and particularly relates to a synthesis method of a 7-quaternary carbon substituted dibenzopyran compound. The preparation method comprises the following steps: mixing a 2 '-isopropenyl-1, 1'-biphenyl-2-phenol compound, an allyl acetate derivative, a palladium catalyst and an organic solvent, and carrying out a Wacker type cross-coupling cascade reaction to synthesize the 7-position quaternary carbon substituted dibenzopyran compound. According to the preparation method, a 2 '-isopropenyl-1, 1'-biphenyl-2-phenol compound and an allyl acetate derivative are taken as initial raw materials, and a Wacker type cross-coupling cascade reaction is carried out under the action of a palladium catalyst, so that a series of 7-quaternary carbon substituted dibenzopyran compounds are obtained. The synthesis method disclosed by the invention is high in yield which can reach 97%, is suitable for synthesis of a series of 7-position quaternary carbon dibenzopyr